Jonathan Epp

Assistant Professor

Cell Biology and Anatomy

Full Member

Hotchkiss Brain Institute

Ph.D. (Doctor of Philosophy)


Contact information

Location

Office: HMRB162

Research and teaching

Research areas

  • Dementia & Cognitive Disorders
  • Neurodevelopment
  • Stress
  • Memory

Research activities

My two primary research interests are in the areas of learning and memory and adult neurogenesis. Specifically, I am interested in memory consolidation and the persistence of memory over time, the underlying neural mechanisms that support this and the pathological conditions that interrupt normal memory processes. An overarching aim is to address questions related to these research topics at multiple levels of analysis. For example, memory stability may relate to synaptic function and spine dynamics (i.e. microscale changes) however I am also interested in investigating the mesoscale and macroscale organization of memory. This can be approached by studying the functional connectivity of different regions throughout the brain.

With respect to adult neurogenesis I am interested in understanding the functional consequences of adding new neurons into existing circuitry. We have previously shown at the behavioural level that adult neurogenesis provides a mechanism for reducing memory interference by enhancing forgetting of old memories. I am now interested in examining how this occurs at the cellular and network level and whether this can be applied to conditions such as dementia or age-related memory loss where memory interference can be a substantial problem.


Publications

PubMed